Supporting Research

1. Clinical application of tobramycin-impregnated calcium sulfate beads in six dogs (2002-2004)

Ham K, Griffon D, Seddighi M, Johnson AL. Clinical application of tobramycin-impregnated calcium sulfate beads in six dogs (2002-2004).  J Am Anim Hosp Assoc. 2008 Nov-Dec;44(6):320-6.

2. Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets

Gauland C. Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets. Adv Skin Wound Care. 2011 Nov;24(11):515-23.

3. Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections

Howlin RP, Brayford MJ, Webb JS, Cooper JJ, Aiken SS, Stoodley P. Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections. Antimicrob Agents Chemother. 2015 Jan;59(1):111-20

4. Reduction in Pseudomonas aeruginosa and Staphylococcus aureus biofilms from implant materials in a diffusion dominated environment.

Moley JP, McGrath MS, Granger JF, Stoodley P, Dusane DH. Reduction in Pseudomonas aeruginosa and Staphylococcus aureus biofilms from implant materials in a diffusion dominated environment. J Orthop Res. 2018 Nov;36 (11)

5. A Single Center Retrospective Evaluation of a Surgical Strategy to Combat Persistent Soft Tissue Wounds Utilizing Absorbable Antibiotic Beads

Gorvetzian J, Kunkel R, Demas C. A Single Center Retrospective Evaluation of a Surgical Strategy to Combat Persistent Soft Tissue Wounds Utilizing Absorbable Antibiotic Beads. Adv Wound Care (New Rochelle). 2019 Feb 1; 8(2): 49–57.

6. Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds

Thomas DB, Brooks DE, Bice TG, DeJong ES, Lonergan KT, Wenke JC. Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds. Clinical Orthopaedics & Related Research. 2005; 441:366-271

7. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion

McKee MD, Li-Bland EA, Wild LM, Schemitsch EH. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma. 2010 Aug;24(8):483-90.

8. Effectiveness of commercially-available antibiotic-impregnated implants

Wenke JC, Owens BD, Svoboda SJ, Brooks DE. Effectiveness of commercially-available antibiotic-impregnated implants. J Bone Joint Surg Br. 2006 Aug;88(8):1102-4.

9. In Vitro Activity of Gentamicin-Loaded Bioabsorbable Beads against Different Microorganisms

Thein E, Tafin UF, Betrisey B, Trampuz A, Borens O. In Vitro Activity of Gentamicin-Loaded Bioabsorbable Beads against Different Microorganisms. Materials (Basel). 2013 Aug 5;6(8):3284-3293.

1. Local and Systemic Levels of Tobramycin Delivered from Calcium Sulfate Bone Graft Substitute Pellets

Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop Relat Res. 2005 Aug;(437):97-104.

2. Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue

Oliver RA, Lovric V, Yu Y, Christou C, Aiken SS, Cooper JJ, Walsh WR. Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue. PLoS One. 2015 Aug 25;10(8):e0136514.

3. The levels of vancomycin in the blood and the wound after the local treatment of bone and soft-tissue infection with antibiotic-loaded calcium sulphate as carrier material

Wahl P, et al. The levels of vancomycin in the blood and the wound after the local treatment of bone and soft-tissue infection with antibiotic-loaded calcium sulphate as carrier material. Bone Joint J. 2017 Nov;99-B(11):1537-1544. doi: 10.1302/0301-620X.99B11.BJJ-2016-0298.R3.

4. Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases

Menon A,Soman R, Rodrigues C, Phadke S, Agashe VM. Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases. J Bone Jt Infect. 2018 May 15;3(2):87-93

5. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets

Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002 Jul;20(4):643-7.

6. Low in vitro third-body wear on total hip prostheses induced by calcium sulphate used for local antibiotic therapy

Heuberger R, Wahl P, Krieg J, Gautier E. Low in vitro third-body wear on total hip prostheses induced by calcium sulphate used for local antibiotic therapy. Eur Cell Mater. 2014 Oct 23;28:246-57.

1. In vitro Elution of Gentamicin From Plaster of Paris Beads

Santschi EM, McGarvey L. In vitro elution of gentamicin from Plaster of Paris beads. Vet Surg. 2003 Mar-Apr;32(2):128-33.

2. In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads

Laycock PA, Cooper JJ, Howlin RP, Delury C, Aiken S, Stoodley P. In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads. Materials (Basel). 2018 Nov 13;11(11).

3. Elution profiles of cefazolin from PMMA and calcium sulfate beads prepared from commercial cefazolin formulations

Udomkusonsri P1, Kaewmokul S, Arthitvong S, Phaochoosak N. Elution profiles of cefazolin from PMMA and calcium sulfate beads prepared from commercial cefazolin formulations. J Vet Med Sci. 2012 Mar;74(3):301-5.

4. Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study

Aiken SS, Cooper JJ, Florance H, Robinson MT, Michell S. Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study. Surg Infect (Larchmt). 2015 Feb;16(1):54-61.

5. Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

Pförringer D, Obermeier A, Kiokekli M, Büchner H, Vogt S, Stemberger A, Burgkart R, Lucke M. Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3897-905.

6. Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads

Wichelhaus TA, Dingeldein E, Rauschmann M, Kluge S, Dieterich R, Schäfer V, Brade V. Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads. J Antimicrob Chemother. 2001 Jul;48(1):117-9.

7. Antibiotic release from impregnated pellets and beads

Bowyer GW, Cumberland N. Antibiotic release from impregnated pellets and beads. J Trauma. 1994 Mar;36(3):331-5.

8. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute

Grimsrud, C., Raven, R., Fothergill, A. W., & Kim, H. T. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute. Orthopedics. 2011 34(8).

1. Antibiotic-impregnated calcium sulfate use in combat-related open fractures

Helgeson MD, Potter BK, Tucker CJ, Frisch HM, Shawen SB. Antibiotic-impregnated calcium sulfate use in combat-related open fractures. Orthopedics. 2009 May;32(5):323.

2. Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection and Revision Arthroplasty - The Use of Synthetic Pure Calcium Sulfate Impregnated with Vancomycin & Tobramycin

Edward McPherson, MD FACS, Matthew Dipane, BA, Sherif Sherif, MD Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection and Revision Arthroplasty – The Use of Synthetic Pure Calcium Sulfate Impregnated with Vancomycin & Tobramycin. Reconstructive Review. 2013; 3:1.

3. Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection

Price BL, Lovering AM, Bowling FL, Dobson CB. Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6880-6889.

4. Surgical intervention for vertebral osteomyelitis in a calf

Shivapour SK, et al. Surgical intervention for vertebral osteomyelitis in a calf. Vet Surg. 2019 Aug;48

5. How to Use Antibiotic Impregnated Plaster of Paris for Alveolar Packing after Tooth Removal

Trostle S, Juzwiak J, Santschi, E. How to Use Antibiotic Impregnated Plaster of Paris for Alveolar Packing after Tooth Removal. AAEP Proceedings. 2000 Vol. 46

6. Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw

Sun HJ, Xue L, Wu CB, Zhou Q. Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw. J Oral Maxillofac Surg. 2017 Jan;75(1):119-128.

7. Simplified Method for Treating Osteomyelitis of the Sternoclavicular Joint

Whitlark JD, Kirollos JA, Jackson SM. Simplified Method for Treating Osteomyelitis of the Sternoclavicular Joint. Ann Thorac Surg. 2016 Mar;101(3):1211-2.

8. Bio-absorbable antibiotic impregnated beads for the treatment of prosthetic vascular graft infections

Genovese EA, Avgerinos ED, Baril DT, Makaroun MS, Chaer RA. Bio-absorbable antibiotic impregnated beads for the treatment of prosthetic vascular graft infections. Vascular. 2016 Dec;24(6):590-597.

9. Absorbable Antibiotic Beads Prophylaxis in Immediate Breast Reconstruction

Kenna DM, Irojah B, Mudge KL, Eveler K. Absorbable Antibiotic Beads Prophylaxis in Immediate Breast Reconstruction. Plast Reconstr Surg. 2017 Dec 13.